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KMID : 0438219750120010283
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Korea University Medical Journal
1975 Volume.12 No. 1 p.283 ~ p.291
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An Experimental Study on Catecholamine Contents in the Uterine and Stomach Tissues of Mature Female Rabbits by Reserpine Administration
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Abstract
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Reserpine, one of the tranquilizers and rauwolfian alkaloids has a number of untoward side effects, such as inhibition or stimulation to the hypothalamus-pituitary-adrenal and hypothalamus-pituitarygonadal axis. The uterus, the target organ of the ovary is also affected by reserpine. Reserpine decreases the blood pressure by controlling Catecholamine level in the cardiac tissue and the circulatory system.
An attempt was made to clarify the effects of reserpine on the Catecholamine contents in the uterine and stomach tissues of mature female albino rabbits weighing around 2.0 kg of body weight.
A group of albino rabbits conditioned with 50 I. U/kg of HCG and another group with 1.0 mg/kg of reserpine plus 50 L U. /kg of HCG were observed in 24 hours after conditioning them. Catecholamine contents were determined by Shore and Olin method.
The results obtained were summarized as follows;
1. The Catecholamine contents in the normal uterine tissue were 0.40 jug/gm, while that of the stomach tissue were 0.15.ug/gm.
2 In the HCG conditioned group, the Catecholamine content in the uterine tissue showed decrease in content as 0.13 jug/gm compared to the normal group whereas in the stomach tissue showed also decrease in content as 0.13 pg/gm.
3. In the reserpine plus HCG conditioned group, the Catecholamine content on the uterine tissue were 0.06 pg/gm, and in the stomach tissue 0.08 pg/gm.
4. The Catecholamine content in the uterine tissue showed marked decrease in the HCG conditioned group and more marked decrease in the reserpine plus HCG conditioned group.
5. The Catecholamine content in the stomach tissue showed no significant difference between normal and HCG conditioned group, but showed remarkable decrease in the reserpine plus HCG conditioned group
6. In the uterine tissue, the catecholamine content showed marked decrease in HCG conditioned group and more marked decrease in reserpine plus HCG conditioned group. But in the stomach tissue catecholamine content showed no change in HCG conditioned group, and marked decrease in reserpine plus HCG conditioned group.
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KEYWORD
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